Benefits of Reishi Mushroom (Plus Side Effects and Dosage)
in Herbal Medicine, Mushroom

Eastern medicine makes use of many different plants and fungi. Interestingly, the reishi mushroom is particularly popular. It has a variety of potential health benefits, including boosting the immune system and fighting cancer. However, its safety has recently come into question.

Reishi Mushroom

Reishi mushrooms are among several medicinal mushrooms that have been used for hundreds of years, mainly in Asian countries, for treatment of infections. More recently, they have also been used in the treatment of pulmonary diseases and cancer.
Medicinal mushrooms have been approved adjuncts to standard cancer treatments in Japan and China for more than 30 years and have an extensive clinical history of safe use as single agents or combined with chemotherapy.
The reishi mushroom is also known as lingzhi.

Why do people take reishi mushroom?

Reishi mushroom has been used to help enhance the immune system, reduce stress, improve sleep, and lessen fatigue. People also take reishi mushroom for health conditions such as: High blood pressure, High cholesterol, Cardiovascular disease, Liver or kidney disease, Respiratory diseases (such as asthma), Viral infections (such as the flu), HIV/AIDS, Cancer and support during chemotherapy, Pain during and after a shingles outbreak, Building strength and stamina and Fatigue.


Reishi mushroom contains chemicals that seem to have activity against tumors (cancer) and beneficial effects on the immune system.


While the mushrooms themselves can be eaten fresh, it is also common to use powdered forms of the mushroom or extracts that contain these specific molecules. These different forms have been tested in cell, animal and human studies.
Below are 6 scientifically studied benefits of the reishi mushroom. The first three are backed by stronger evidence, while support for the others is less conclusive.



1. Boost the Immune System

One of the most important effects of the reishi mushroom is that it can boost your immune system. While some details are still uncertain, test-tube studies have shown that reishi can affect the genes in white blood cells, which are critical parts of your immune system. What’s more, these studies have found that some forms of reishi may alter inflammation pathways in white blood cells. Research in cancer patients has shown that some of the molecules found in the mushroom can increase the activity of a type of white blood cell called natural killer cells .

Natural killer cells fight infections and cancer in the body. Another study found that reishi can increase the number of other white blood cells (lymphocytes) in those with colorectal cancer. Although most immune system benefits of reishi mushroom have been seen in those who are ill, some evidence has shown that it can help healthy people, too. In one study, the fungus improved lymphocyte function, which helps fight infections and cancer, in athletes exposed to stressful conditions.

However, other research in healthy adults showed no improvement in immune function or inflammation after 4 weeks of taking reishi extract. Overall, it is clear that reishi impacts white blood cells and immune function. More research is needed to determine the extent of the benefits in the healthy and ill.

“ Reishi mushroom can enhance immune function through its effects on white blood cells, which help fight infection and cancer. This may occur primarily in those who are ill, as mixed results have been seen in those who are healthy.”



2. Anti-Cancer Properties

Many people consume this fungus due to its potential cancer-fighting properties. In fact, one study of over 4,000 breast cancer survivors found that around 59% consumed reishi mushroom. Additionally, several test-tube studies have shown that it can lead to the death of cancer cells. Yet the results of these studies do not necessarily equate to effectiveness in animals or humans.

Some research has investigated if reishi could be beneficial for prostate cancer due to its effects on the hormone testosterone. While one case study showed that molecules found in this mushroom may reverse prostate cancer in humans, a larger follow-up study did not support these findings. Reishi mushroom has also been studied for its role in preventing or fighting colorectal cancer. Some research showed that one year of treatment with reishi decreased the number and size of tumors in the large intestine.

What’s more, a detailed report of multiple studies indicated that the mushroom can beneficially affect cancer patients. These benefits included increasing the activity of the body’s white blood cells, which help fight cancer, and improving quality of life in cancer patients. However, researchers state that reishi should be administered in combination with traditional treatment rather than replacing it. What’s more, many of the studies of reishi mushroom and cancer were not high-quality. Because of this, much more research is needed.

“ Although reishi mushroom appears to hold some promise for cancer prevention or treatment, more information is needed before it becomes part of standard therapy. However, it may be appropriate to use in addition to normal care in some cases.”



3. Could Fight Fatigue and Depression

Reishi’s effects on the immune system are often most emphasized, but it has other potential advantages as well. These include reduced fatigue and depression, as well as improved quality of life. One study examined its effects in 132 people with neurasthenia, a poorly defined condition associated with aches, pains, dizziness, headaches and irritability. The researchers found that fatigue was reduced and well-being was improved after 8 weeks of taking the supplements.

Another study found that fatigue was reduced and quality of life was improved after 4 weeks of taking reishi powder in a group of 48 breast cancer survivors. What’s more, the people in the study also experienced less anxiety and depression. While reishi mushroom may hold promise for people with certain diseases or illnesses, it is not clear if it would benefit those who are otherwise healthy.

“ Some preliminary studies have shown that reishi mushroom could decrease anxiety and depression as well as improve quality of life in those with certain medical conditions.”



4–6. Other Potential Benefits

In addition to its effects on the immune system and quality of life, reishi mushroom has been studied for its potential to improve other aspects of health.


4. Heart Health

One 12-week study of 26 people showed that reishi mushroom may increase “good” HDL cholesterol and decrease triglycerides. However, other research in healthy adults showed no improvement in these heart disease risk factors.

Moreover, a large analysis demonstrated no beneficial effects for heart health after examining five different studies containing around 400 people. The researchers found that consuming reishi mushroom for up to 16 weeks did not improve cholesterol. Overall, more research is needed in regard to reishi mushrooms and heart health.



5. Blood Sugar Control

Several studies have indicated that molecules found in the reishi mushroom can decrease blood sugar in animals. Some preliminary research in humans reported similar findings. However, the majority of research has not supported this benefit. After evaluating hundreds of participants, researchers found no benefits for fasting blood sugar.

Mixed results were seen for blood sugar after meals. In some cases, reishi mushroom lowered blood sugar, but in other cases, it was worse than a placebo. Again, more research is needed here as well.



6. Antioxidant Status

Antioxidants are molecules that can help prevent damage to your cells. Because of this important function, there is substantial interest in foods and supplements that can enhance antioxidant status in the body. Many claim that reishi mushroom is effective for this purpose.

However, several studies have found no change in the levels of two important antioxidant enzymes in the blood after consuming the fungus for 4 to 12 weeks.

“ A small amount of research has shown that reishi mushroom could improve good cholesterol or blood sugar. However, the majority of the research indicates that it does not improve cholesterol, blood sugar or antioxidants in the body..”

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